Bioactive Small Molecules
Cayman Chemical MAGL Inhibitor Compound 23
An inhibitor of MAGL (IC50 = 80 nM); selective for MAGL over CB1, CB2, FAAH, ABHD6, and ABHD12 (IC50s = >10 μM); inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM); increases the levels of 2-AG in mouse brain and plasma at 50 mg/kg
Cayman Chemical ANTIBODY GSK180736A 25mg
A ROCK1 and GRK2 inhibitor (IC50s = 14 and 0.77 µM, respectively); selective for GRK2 over GRK1, GRK5, and PKA (IC50 = >100 µM for all); selective for ROCK1 over RSK1 and p20S6K (IC50s = 3,100 and 2,850 nM, respectively); increases maximum contractility in isolated mouse cardiomyocytes at 1 µM
Medchemexpress LLC DFBTA | 2966044-07-3 | 99.3% | 393.79 | 50 MG
DFBTA is an orally active and potent ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM. It shows analgesic efficacy for inflammatory pain. For research use only and not sold to patients.
- Orally active and potent ANO1 inhibitor
- IC50 of 24 nM for ANO1
- Shows analgesic efficacy for inflammatory pain
- Very weak cytotoxicity and cardiotoxicity (HEK293 proliferation IC50 > 30 μM, hERG IC50 > 30 μM)
- Weak acute toxicity in mice (MLD > 1000 mg/kg)
- Excellent pharmacokinetics properties with oral bioavailability > 75%
- Little brain penetration (<1.5% brain/plasma)
Medchemexpress LLC (-)-DHMEQ | 287194-40-5 | 99.8% | 261.23 | 1 ML
(-)-DHMEQ is a potent, selective, and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. It inhibits nuclear translocation of NF-κB and demonstrates anti-inflammatory and anticancer activity.
- Potent, selective, and irreversible NF-κB inhibitor
- Covalently binds to a cysteine residue
- Inhibits nuclear translocation of NF-κB
- Demonstrates anti-inflammatory activity
- Demonstrates anticancer activity
Cayman Chemical ANTIBODY GM 1489 5mg
An MMP inhibitor (Kis = 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively); reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression in as well as cell invasion by AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells; inhibits TPA- and PdiBu-induced increases in EAr thickness and epidermal hyperplasia in mice at 100 μg, topical
eMolecules 2957-21-3 | Medchem Express | Sakuranetin | 5mg | 455326359 | HY-N3006 | MFCD00075651 | 286.283 | C16H14O5
Ambeed | 24-Dimethylbenzamide | 1g | 660580533 | A113283 | 73258-94-3 | MFCD11643208 | 149.193 | C9H11NO
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Cayman Chemical WKYMVmtrIfluoroacetAT salt 5mg
A synthetic peptide agonist of FPR1 and FPR2; induces calcium mobilization in ETFR cells transfected with FPR1 or FPR2 at 0.1 nM; stimulates chemotaxis of monocytes, dendritic cells, and NK cells, as well as superoxide production in monocytes and neutrophils, in vitro; reverses mucosal destruction, decreases in body weight, and colonic shortening in a mouse model of DSS-induced colitis at 8 mg/kg; topical application stimulates angiogenesis and accelerates re-epithelialization and granulation tissue formation in a rat model of diabetic cutaneous wounds
![Medchemexpress LLC Hexadecanamide-13,13,14,14,15,15,16,16,16-d9, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)] | 2260669-53-0 | 99.0% | 564.97 | C34H60D9NO4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222738.png-250.jpg)
Medchemexpress LLC Hexadecanamide-13,13,14,14,15,15,16,16,16-d9, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)] | 2260669-53-0 | 99.0% | 564.97 | C34H60D9NO4 | 5 MG
CER3-d9 is a deuterium-labeled analogue of CER3 supplied for research use as a tracer or internal standard in quantitative analyses. Supplied as a solid in a 5 mg package, it provides high chemical and isotopic purity suitable for analytical workflows including NMR, GC-MS, and LC-MS.
- Deuterium-labeled analogue useful as tracer or internal standard
- High purity and isotopic enrichment for accurate quantitation
- Suitable for NMR, GC-MS, and LC-MS applications
- Provided as a solid in a small, research-scale package
- Intended for research use only and not for human use
Medchemexpress LLC 3,3'-Difluorobenzaldazine | 15332-10-2 | MFCD03653615 | 99.4% | 244.24 | C14H10F2N2 | 5 MG
3,3'-Difluorobenzaldazine (DFB) is a small-molecule research compound reported as a selective positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It is intended for preclinical and in vitro research and is characterized by defined molecular properties and high batch purity.
- Selective positive allosteric modulator of mGluR5.
- High purity suitable for research applications.
- Available in multiple small-scale pack sizes for screening and dose-response studies.
- Molecular formula C14H10F2N2; molecular weight 244.24.
- Supplied with batch-specific certificate of analysis for traceability.
Medchemexpress LLC Diethylstilbestrol-d8 | 91318-10-4 | MFCD01074086 | 99.7% | 276.40 g·mol⁻¹ | C18H12D8O2 | 5 MG
Diethylstilbestrol-d8 is the deuterium-labeled analogue of diethylstilbestrol supplied as a solid stable-isotope internal standard for analytical and research use. It is intended as a tracer or internal standard for quantitative NMR, GC-MS, and LC-MS assays and has high isotopic purity suitable for precise analytical quantitation.
- Deuterium-labeled internal standard for quantitative analysis.
- Suitable for NMR, GC-MS, and LC-MS assays.
- High isotopic purity (≈99.7%).
- Soluble in DMSO (≈50 mg/mL); ultrasonic warming recommended.
- Stable solid with recommended cold storage for long-term preservation.
- Supplied in small analytical quantities for tracer and standard applications.
Medchemexpress LLC Cyclohexanepropanoic acid, 2-(dimethylamino)ethyl ester | 15585-86-1 | MFCD00868086 | 98.0% | 227.34 g/mol | C13H25NO2 | 50 MG
Cyprodenate is an orally active, blood-brain barrier-penetrant stimulant supplied for laboratory research use only. The product is provided as a 50 mg vial at high purity and is suitable for in vitro and in vivo formulation following laboratory protocols.
- Has CAS number 15585-86-1.
- Molecular formula C13H25NO2 and molecular weight 227.34 g/mol.
- Purity 98.0% by manufacturer specification.
- Highly soluble in DMSO (≥ 200 mg/mL) and formulatable for in vivo use (≥ 5 mg/mL in recommended vehicles).
- Appearance: off-white to light brown liquid; density ~0.958 g/cm3.
- Storage: store product at 4°C and protect from light; in solution store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Mog (35-55) (acetate) | 149635-73-4 | 99.7% | 2581.95 | 25 MG
MOG (35-55) mouse, rat, a minor component of CNS myelin, exhibits encephalitogenic activity and stimulates T cell proliferation. It induces a Th1 cytokine response and high levels of IgG antibodies, leading to a relapsing-remitting neurological disease with extensive plaque-like demyelination. This product is suitable for experimental autoimmune encephalomyelitis (EAE) modeling.
- Exhibits encephalitogenic activity
- Stimulates T cell proliferation
- Induces Th1 cytokine response
- Increases IgG levels in vitro
- Useful for experimental autoimmune encephalomyelitis (EAE) modeling
- Triggers immune response against the central nervous system
Enzo Life Sciences Genistein (synthetic) (10mg). CAS: 446-72-0
Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Potent inhibitor of α-glucosidase, IC50 = 50nM.Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC50=20µM). Alternative name: 4',5,7-Trihydroxyisoflavone. Purity: ≥98% (HPLC). Appearance: Creamy off-white solid. Solubility: Soluble in DMSO (30mg/ml), 100% ethanol (4mg/ml) or dilute aqueous base; insoluble in water. Long Term Storage: -20°C.
Medchemexpress LLC HIF-2α agonist 2 | 2750141-15-0 | C13H8Br2N2O2S | 5 MG
HIF-2α agonist 2 is an agonist that activates HIF-2 with an EC50 value of 1.68 μM at a dose of 20 μM. It is non-cytotoxic against 786-O-HRE-Luc cells and can be used for oxygen metabolism research.
- Activates HIF-2 with an EC50 value of 1.68 μM
- Non-cytotoxic against 786-O-HRE-Luc cells
- Useful for oxygen metabolism research
Medchemexpress LLC Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate | 1566559-80-5 | C57H114N4O6 | 5 MG
Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate is a biodegradable lipid prepared by the conjugate addition of alkylamines to acrylates. This compound can be utilized in various drug delivery systems for the delivery of polynucleotides, such as siRNA.
- Purity: 98.71%
- Molecular weight: 951.54
- Appearance: Liquid, colorless to light yellow
- Density: 0.943±0.06 g/cm³
- Shipping: Room temperature in continental US, may vary elsewhere
- Storage: -20°C, protect from light, stored under nitrogen
- Storage in solvent: -80°C for 6 months, -20°C for 1 month (protect from light, stored under nitrogen)
- Solubility in vitro: Ethanol at ≥ 100 mg/mL (105.09 mM)